Technology
Denaturator
The denaturator was developed to rapidly process samples prior to the diagnostic test. The device is a battery-powered boiling unit that rapidly heats samples to 90-100°C within 90 seconds. The samples are extracted in our lysis solution containing detergent, which ruptures cells and strips the proteins from RNA or DNA, making the nucleic acids accessible for diagnostic testing. The denaturator can process up to 75 individual samples on a single battery charge. The samples are then processed through the S-TECH filter to produce highly purified nucleic acids for LAMP amplification.
S-TECH extraction technology
The S-TECH is DNAiTECH's extraction system, developed for extracting nucleic acids after sample heating and cell rupture using the denaturator. The extraction of nucleic acids using S-TECH is described here.
S-TECH can also enable the isolation of subcellular particles, such as extracellular vesicles and microvesicles, using our nanopore track-etched polycarbonate membranes. A demonstration of S-TECH PCTE membranes for the recovery of subcellular particles from urine and serum is shown here.
Gen 3.2 chip technology system
The Gen 3.2 hardware is our latest version of our POC systems, representing an evolution of our Gen 3.1 system. Gen 3.2 integrates LAMP and CRISPR into a single step real-time capable diagnostic system. The first version of Gen 3.2 is due for release in September 2026. The Gen 3.2 system has 8 reaction wells in a linear format and is designed for multichannel pipette loading. Beyond version 3.2, Gen 3.3 is due for release in 2027 and will have the optical systems for real-time processing. Gen 3.2/3 are to be battery-powered with a minimum of 1 day of full battery operation.
Gen 3.2/3 will screen for multiple pathogens simultaneously. Gen 3.1 data is found here.
